A Rhône voyage almost always includes the Saône, and the two behave differently. The Saône is slow, wide and placid through Burgundy; the Rhône below Lyon is a powerful river falling towards the Mediterranean, and it was heavily engineered in the twentieth century with large dams and deep locks to make it dependable for navigation and power.
The consequence for a passenger is that the two halves of the same voyage feel unlike each other. The Burgundy stretch is gentle sailing between small towns; the Rhône stretch involves big locks, faster water and a landscape that turns progressively southern — vineyards, then olive trees, stone villages and Roman remains.
Direction matters here more than on most rivers. Sailing downstream with the current is quicker than working back up against it, which is why southbound and northbound voyages over the same route do not spend their time in the same way.